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This can be done using class eduorg.mayoapache.bmictakes.uimadictionary.lookup.ae.FirstTokenPermLookupInitializerImpl as the lookupInitializer, and using class OrangeBookFilterConsumerImpl as the lookupConsumer, provided you have the RxNorm dictionary, and you configure the LookupDescriptorFile resource to use your RxNorm dictionary.
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A LookupDescriptorFile such as lookup/LookupDesc.xml, found in resources/, defines the dictionary(s) used, and the classes that interact with the dictionary(s). The implementation tag identifies the type of dictionary: Lucene index (luceneImpl), database (jdbcImpl), or delimited flat file (csvImpl). See class eduorg.mayoapache.bmictakes.uimadictionary.lookup.ae.LookupParseUtilities.java for implementation details.
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The programs used to create these Lucene indexes are scripts/java/edu/mayo/bmi/dictionarytoolsorg/apache/ctakes/dictionary/lookup/tools/CreateLuceneIndexForExampleDrugs.java and scripts/java/org/eduapache/ctakes/mayodictionary/bmilookup/dictionarytoolstools/CreateLuceneIndexForSnomedLikeSample.java
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Alternatively, you could use a different program in that same package that reads from a pipe-delimited file:\\
scripts/java/org/eduapache/ctakes/mayodictionary/bmilookup/dictionarytools tools to create a Lucene index.