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http://www.spamtips.org/p/ultimate-setup-guide.html

IRC / Mailing List

If you have done everything above, and are still not having satisfactory results, the next step is to provide some examples of spams being missed, with complete headers, to people who can provide suggestions, via something like pastebin.com - don't paste this stuff in the bodies of emails or include it as attachments. The IRC channel #spamassassin on irc.freenode.net may help, but it is unfortunately not very active. The relevant mailing list is the spamassassin users list.