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If you are using a component which defaults to InOut you can override the Exchange Pattern for an endpoint using the pattern property.

foo:bar?exchangePattern=InOnly

From 2.0 onwards on Camel you can specify the Exchange Pattern using the dslDSL.

Using the Fluent Builders

from("mq:someQueue").
  inOnlysetExchangePattern(ExchangePattern.InOnly).
  bean(Foo.class);

or you can invoke an endpoint with an explicit pattern

from("mq:someQueue").
  inOnly("mq:anotherQueue");

Using the Spring XML Extensions

<route>
    <from uri="mq:someQueue"/>
    <inOnly uri="bean:foo"/>
</route>

<route>
    <from uri="mq:someQueue"/>
    <inOnly uri="mq:anotherQueue"/>
</route>